Comparison of Biochemical effects of glibenclamide and some trace elements on experimental diabetic rats

Document Type : Original Article

Authors

1 Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University, Egypt

2 Department of Biochemistry and Nutrition, Faculty of Veterinary Medicine, Cairo University, Egypt

Abstract

The present work was done to elucidate the possible protective and antidiabetic effect of chromium chloride (Cr) (500 mg/k.g.), sodium selenite (Se) (1.5 mg/k.g.) and Zinc sulphate (Zn) (54 mg/k.g.) supplementation in streptozotocin induced diabetic rats. Oral administration of both Cr+3 and Zn+2 as well as intraperitoneal injection of Se-2 at concentrations of 500, 1.5 and 54 mg/kg b.w. daily, respectively for 60 days showed a significant decrease in fasting blood. The treatment also resulted in a significant increase in plasma C-peptide and trace elements Cr+3 and Zn+2 and Se-2. The trace elements exerted rapid protective effects against lipid peroxidation by scavenging of free radicals  by reducing the risk of diabetic complications. 

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