Biochemical effect of alpha –lipoic acid on oxidative stress and dysfunction in experimentally induced myocardial infarction

A. El Maksoud, Hussein; Mahrous, Usama E.; El-far, Ali H.; Sadek, Kadry M.; Ajaj, Al-Hossain H. Ali

doi:10.21608/sjou.2017.30463

Biochemical effect of alpha –lipoic acid on oxidative stress and dysfunction in experimentally induced myocardial infarction

Document Type : Original Article

Authors

¹ Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt

² Biochemistry Department, Faculty of Vet. Med. Moshtohor, Benha University, Egypt.

³ Animal and Poultry Behavior, Faculty of Vet. Med. Damnhour University, Egypt

⁴ Lectuerer of Biochemisry, Faculty of Vet. Med. Damnhour University, Egypt.

10.21608/sjou.2017.30463

Abstract

The present study was designed to evaluate the protective effect and treatment effect of Alpha lipoic acid administration on cardiac necrosis markers, some electrolytes and cardiac tissue antioxidants in myocardial necrosis induced experimentally in rats- The investigated serum and cardiac biochemical parameters were: A) Serum levels of creatine kinase (CK) ,creatine kinase MB (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), total protein (T.P), albumin (Alb), glucose, calcium (Ca), sodium (Na), potassium (K), phosphorus (P). B) RBCs glucose 6 phosphate dehydrogenase (G-6-PDH). C) Cardiac antioxidants (SOD and CAT) and cardiac oxidant (MDA).

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