Antitumor and Antioxidant Activity of Gold Nanoparticles: In vitro and In vivo Study

Document Type : Original Article

Authors

1 Industrial Biotechnology Department, GEBRI Institute, Sadat City University, Egypt

2 Environmental Biotechnology Department, GEBRI Institute, Sadat City University, Egypt

Abstract

Gold nanoparticles (AuNPs) have been tested in vivo and in vitro for its antioxidant and antitumor activity, cytotoxicity of AuNPs have been studied in vitro and found that a concentration of 7 mg/ml decrease the EAC count by 41.8%. There was a very high significant increase in catalase (CAT) activity by 90.6% and very high significant decrease in malonodialdehyde (MDA) level, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum creatinine by 30.8%, 36.1%, 27% and 56.1% respectively.

Main Subjects