Biochemical study on rule of Sonchus oleraceus L. Extracts against Paracetamol-Induced Liver toxicity

Hussein, Mohammed A.; Gobba, Naglaa A.

doi:10.21608/sjou.2014.32865

Biochemical study on rule of Sonchus oleraceus L. Extracts against Paracetamol-Induced Liver toxicity

Document Type : Original Article

Authors

¹ Biochemistry Department, Faculty of Pharmacy, October 6 University, October 6 city, Egypt

² Pharmacology Department, Faculty of Pharmacy, Misr University for Science & Technology (MUST), October 6 city, Egypt

10.21608/sjou.2014.32865

Abstract

Sonchus oleraceus L. extracts (ethanolic and aqueous) were evaluated for hepatoprotective activity against liver toxicity induced by paracetamol. Oral administration of both extracts at a concentration of 150 mg/kg b.w daily for 15 days showed a significant protection against-induced alteration in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and concentrations of thiobarbituric acid reactive substances (TBARS), protein thiols (Pr-SHs), reduced glutathione (GSH), by paracetamol. The results from the present investigation were supported by histopathological findings that demonstrated regeneration of hepatocytes in treated animals, which was indicative of the protective effects of the extracts. Thus the results obtained indicate that (ethanolic and aqueous) extracts of Sonchus oleraceus L. possess hepatoprotecive effect and these explicate justification of the use of this plant in the treatment of oxidative stress disease conditions.

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